Malte Gersch
PRINCIPAL INVESTIGATOR
Malte Gersch studied Chemistry and Biochemistry at LMU Munich. Following a research internship in the laboratory of Prof. Dr. Matthew Bogyo at Stanford University, he pursued his PhD in Chemical Biology with Prof. Dr. Stephan A. Sieber at TU Munich on chemical tools to dissect mechanisms of bacterial ClpP proteases. He subsequently joined the laboratory of Dr. David Komander at the MRC Laboratory of Molecular Biology (LMB) in Cambridge, UK, for post-doctoral training in structural biology, where he investigated the structure, function and inhibition of human deubiquitinases. Research in his group aims to investigate and therapeutically target proteolysis in the ubiquitin system. A multidisciplinary approach combining organic synthesis, chemical and structural biology and cellular assays is employed. His laboratory is jointly affiliated with the Technical University Dortmund, Department of Chemistry and Chemical Biology, and the Max-Planck-Institute of Molecular Physiology, Chemical Genomic Centre. Funding through an Emmy-Noether fellowship awarded by the Deutsche Forschungsgemeinschaft (DFG), and by the pharmaceutical companies Pfizer, AstraZeneca and Merck, is gratefully acknowledged. In 2024, he was recognised with the Biomedicine award and the ORCHEM award.